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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9503 | PHYTOSPHINGOSINE | Apoptosis | |
Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax. | |||
T16133 | MRK-560 | Gamma-secretase | |
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. | |||
T6603 | Nelarabine | GW 506U78,Nelzarabine,506U78 | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. | |||
T3977 | Lifitegrast | SHP-606,SAR 1118 | Integrin |
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist. | |||
T0370 | Pheniramine maleate | Daneral,Inhiston,Trimetose | 5-HT Receptor , Histamine Receptor |
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... | |||
T64387 | 2-Nitrobenzoic acid | o-Nitrobenzoic acid | Others |
2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25. | |||
T35569 | CTA 056 | Apoptosis | |
CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel... | |||
TL0013 | Heraclenin | Anti-infection , Immunology/Inflammation related | |
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Her... | |||
T10565 | BMS-1001 hydrochloride | PD-1/PD-L1 | |
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat... | |||
T24816 | SP-100030 | SP100030,SP 100030 | NF-κB |
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ... | |||
T5320 | Tulipalin A | α-methylene-γ-butyrolactone,2-Methylenebutyrolactone | Others , Drug Metabolite |
Tulipalin A (α-methylene-γ-butyrolactone) (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana. | |||
T39342 | 4-Maleimidosalicylic acid | ||
4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells. | |||
TN3734 | Cuspidiol | Others | |
Cuspidiol shows cytotoxicity against Jurkat T cell clone E6.1 at 7.3 ug/mL. | |||
T80497 | KTX-Sp2 | Potassium Channel | |
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3 channel and suppresses Ca2+ signaling in Jurkat T cells. Ad... | |||
T12203L | Necrostatin 2 | Others | |
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. | |||
T14003 | 15-Acetoxyscirpenol | Caspase | |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activat... | |||
TP2101 | Z-VRPR-FMK trifluoroacetate salt | ||
Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. | |||
T36331 | Z-AEVD-FMK | Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone | |
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its activ... | |||
T35906 | Padanamide A | ||
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines... | |||
T36961 | Malformin C | ||
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human... |